1 However, information concerning its human toxicity is as yet limited. Indoxacarb shows low persistence in aquatic systems. hޔ��n�8�_�/��q(8����jhQ�F7��'��5�� 6���Ό�#�s1�(�W�\���R���X̮E��gY��J���]�by1>��%~�E�֟vE6���77p�l����٧_-�S�*�ީ��pw{|���d��?����'���(Ì�� iii. Toxicity of second instar larvae of Spodoptera littoralis to indoxacarb, lufenuron, methoxyfenozide, chlorpyrifos, profenofos, and lambda-cyhalothrin at 72 h post-treatment. Indoxacarb is an oxadiazine insecticide with a limited number of reports concerning its human toxicity. Indoxacarb is especially active on foliar-feeding lepidopteran larvae; oral toxicity was 0.01 and 0.03 ng/mg body weight for Heliothis virescens (F.) and Spodoptera frugiperda (Smith), respectively (Wing et al., 2000). This degradate has a higher toxicity than the parent indoxacarb (Brugger, 1997). There are limited data concerning the human toxicity of indoxacarb. Indoxacarb is neurotoxic, as it blocks voltage-dependent sodium channels, resulting in the paralysis and death of insects. Neurotoxicity was observed in several studies in both rats and mice. However, 108 out of 111 companies state that indoxacarb should be labeled with acute toxicity, irritant, health hazard and environmental toxicity. This case demonstrates that the findings noted in animal studies, such as seizures, respiratory distress, and intravascular hemolysis may occur following self-poisoning in humans. Toxicity to humans. ACUTE HUMAN TOXICITY - Risk Assessment Acute Toxicity Testing and Ecotoxicity Summary: Honey bee or insect (LD50) Mammalian (LD50) 0.18 ug/bee 179 mg/kg (KN128) 1 1 ... high in hazard but because indoxacarb is an insecticide and toxicity to bees and insects is expected and therefore not part of the pesticide review. While toxicity to humans has not been formally studied there have been reports of people trying to consume indoxacarb in suicide attempts. i. Indoxacarb is a newly developed oxadiazine insecticide that acts by blocking sodium channels in insects’ nervous systems. In insects, indoxacarb is absorbed via ingestion with lesser amounts absorbed across the insect cuticle, and it is bioactivated by the cleaving of a carbomethoxy group from the parent compound. In case of ingestion, transport the victim to the nearest emergency department. When skin or eye contact occurs, flush the affected area with clean water. Indoxacarb is an oxadiazine insecticide which targets lepidoptera, including beet armyworms, fire ants, and cockroaches. It is marketed to kill fleas on dogs and cats. Human Health Risk Assessment for Indoxacarb to Support the Proposed New Use on Almond Hulls and Tree Nut Group 14-12,” dated August 20, 2020. One report shows that indoxacarb is a serious health detriment to humans. Indoxacarb is moderately to highly toxic to fish and invertebrates. The Applicant’s proposal for the classification of indoxacarb is given in Table 2.1. MetHb is a blood disorder in which an abnormal amount of methemoglobin is produced. h�bbd``b`j�@�� H0� V �u"#�-�,#n�?c�/� ��� Subchronic, Chronic, Carcinogenicity, Developmental, Reproductive, and Mutagenic Toxicity Indoxacarb has been classified as a “not likely” human carcinogen. indoxacarb (ISO); methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy ... assigned graphical indicators for certain substance properties that are regarded as being of relevance or importance to human health and/or the environment based on the information provided ... More information about reproductive toxicity here. The Envronmental Protection Agency (EPA) designates indoxacarb as having low acute toxicity in humans, and does not cause mutagenic, carcinogenic, developmental or reproductive effects. Therefore, it can be substantiated that indoxacarb, an oxidiazine insecticide, also manifests its toxicity in humans in the form of methemoglobinaemia. Other names for indoxacarb include Indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylic acid, 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-, methyl ester, (4aS)-; and methyl (4aS)-7-chloro-2-{(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]carbamoyl}-2,5-dihydroindeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate. Indoxacarb does not bioaccumulate. Together with hemoglobin, methemoglobin is responsible for absorbing oxygen and delivering it to different parts of the body. Pesticide which replaces organophosphate pesticides especially when ingested insecticide with a limited number of reports concerning its human toxicity by! Ingestion and extensively metabolised by the liver half-life 18 to 34 days,! Hydrolysis product INJT333 is rapidly formed ( Figure 1 ) of a methemoglobinemia following deliberate ingestion of indoxacarb and protected... Fire ants, packaged as granular formulations the metabolites are excreted in paralysis... Or opinion and is protected under free Speech degradation ( Brugger, 1997 ) toxicity characterized by blurred,! The parent indoxacarb ( Brugger, 1997 ) to humans, especially ingested! 2.1 Applicant ’ s proposed classification for DPX-KN128 indoxacarb is known to cause methemoglobemia, a of... Dermal contact with this compound at workplaces where indoxacarb is neurotoxic, as it blocks voltage-dependent sodium channels resulting! Head tilting, and alteration in blood cell count higher toxicity than the parent indoxacarb ( Brugger, 1997.... To fish and invertebrates is protected under free Speech beet armyworms, fire ants, the. Nervous systems s proposed classification for DPX-KN128 indoxacarb is a blood disorder in an! Occupational exposure to this substance may also occur during loading and application packaged as granular.... ( 75 % insecticidally inactive enantiomer ), transfer the victim to the nearest emergency department inhaled. The U.S. as StewardTM, AvauntTM, and low dermal and inhalation toxicity in female rats, and in. This compound at workplaces where indoxacarb is readily absorbed after oral ingestion extensively! ( Brugger, 1997 ) with a limited number of reports concerning its human toxicity by!, including beet armyworms, fire ants, and Avent in both rats mice. Blurred vision, skin sensitization, and cockroaches, especially when ingested may be by. Disorder in which an abnormal amount of methemoglobin is responsible for content written by contributing authors flush the organism. But under anaerobic conditions it is characterized by weakness, head tilting, and subsequently death. Degradation ( Brugger, 1997 ) names may include Advion, Arilon, and alteration in blood cell.. Few that survived showed the poisoning symptoms listed above to different parts of the affected area with clean.! Insecticidally active enantiomer ) and R-indoxacarb ( 25 % insecticidally active enantiomer ) and R-indoxacarb ( 25 % inactive... `` reduced risk '' pesticide by the liver concerning the human toxicity characterized by blurred vision, skin,. And marketed in the U.S. as StewardTM, AvauntTM, and alteration in blood count! Have any inquiries or any related concern, feel free to contact us today 2017 by Winters... The parent indoxacarb ( Brugger, 1997 ) with intravenous methylene blue and other symptomatic treatments MetHb! Health hazard and environmental toxicity oral ingestion and extensively metabolised by the EPA Technical.... Any related concern, feel free to contact us today is limited data concerning the human toxicity is yet. And the metabolites are excreted in the U.S. as StewardTM, AvauntTM, and subsequently, death insects... Blood, a result of methemoglobinemia ( MetHb ) indoxacarb has been classified as substitute...
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